A NEW EXPERIMENTAL MODEL OF PERIODONTITIS IN RATS

Background: The global prevalence of periodontal disease in adults is estimated up to 60-90%. Thus, development new methods for diagnosis and treatment periodontitis with their approbation on animal models important. Aim: To create an experimental model rats the best possible simulation clinical manifestations humans according current understanding etiology pathogenesis this disease. Methods: experiment was performed 20 male Wistar (230±20 g). According proposed methodology, modeled by placing a metal ligature gingival margin lower incisors figure eight-shaped manner fixing it alveolar bone thus destroying ameloblastic epithelium. Periodontal inflammation studied clinically histologically. Microcirculation parameters were analyzed Doppler ultrasound. Results: use associated inflammation, hyperperfusion causing oxidative stress destruction: Vas, Vakd Vam significantly increased 40.0% (p=0.007), 60.63% (p=0.005) 83.33% (p=0.005), respectively. Also, there significant decreases Gosling (PI) Stewart (SD) indices: 63.82% (P=0.008) 20.39% (p=0.005). Conclusion: developed easily reproducible similar characteristics humans, decrease modeling time 7 days simplifying developments periodontitis.